TMS and fMRI Study for Depression and Anxiety

Inclusion for patients: * Diagnosis of major depressive disorder * Age greater than or equal to 18 years * Age less than or equal to 65 years * Able to understand and consent for research participation * English-speaking Inclusion for healthy controls: * Report no lifetime psychiatric diagnosis and treatment * scores on Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD-7) lower than 4 * Age greater than or equal to 18 years * Age less than or equal to 65 years * Able to understand and consent for research participation * English-speaking Exclusion for all subjects: * Age less than 18 years * Age greater than 65 years * With epilepsy or seizure disorder * With implanted ferromagnetic equipment in their face or skull near the stimulation target MRI Exclusion criteria for all subjects: * Implanted device including pacemaker, coronary stent, defibrillator, or neurostimulation device that is not MRI-compatible * Metal in body including bullets, shrapnel, metal slivers * Claustrophobia * Uncontrolled high blood pressure * Blood circulation problems * Opiate medication, antihypertensive medication, or any medication that interferes with blood flow (interferes with fMRI recordings) * Significant heart disease, such as atrial fibrillation * Pregnancy in female participants * Prior exposure to deep brain stimulation, rTMS, or tDCS (transcranial direct current stimulation) therapies * History of neurological or cardiovascular disorders, brain surgery, radiation treatment, brain hemorrhage or tumor, stroke, or diabetes * Significant traumatic brain injury (loss of consciousness, post-injury amnesia, significant radiological/neurological findings, penetrating brain injury) * Refusal to abstain from illicit drug use for duration of the study * Refusal to abstain from alcohol within 24 hours of scans If you would like to participate in the study, click this link to fill out the Screening Form: https://redcap.icts.uiowa.edu/redcap/surveys/?s=DEYHWF8TMCHHW4Y7. Kindly note that our research team will contact you directly only if you meet the eligibility criteria for the study. Due to the high volume of responses, we are unable to reply to individual inquiries or provide feedback about eligibility decisions.