No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 60
Sex
Any
Study type
Observational
Participants needed
200 (estimated)
Sponsor
University of Iowa · Other
Who this trial is looking for
This trial is looking for adults who are carrying the cystic fibrosis gene or are not carriers. Participants will answer questions about their health and experience a heat challenge in a sauna.
Are You a Good Fit for This Trial?
You may be able to join if
I have been genotyped as a CF carrier or control
I can speak and read English
You may not be able to join if
I have been genotyped as a CF patient
I have been diagnosed with Type 1 or Type 2 diabetes
I have had a heart attack, stroke, heart failure, or atherosclerosis
I am currently pregnant
I am taking beta blockers or diuretics
I am a prisoner
I cannot provide my own written informed consent
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.
The primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort.
This will be accomplished with two smaller proj…
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.
The primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort.
This will be accomplished with two smaller projects- Aim 1 and Aim 2.
Aim 1 will consist of 100 CF Carriers and 100 age- and sex-matched controls. Participants in this aim will be asked to complete a Participant Info and Temperature Survey consisting of questions about race, ethnicity, medical history, and how they experience heat.
Aim 2 will consist of a subset of 25 CF Carriers and 25 age- and sex-matched controls from Aim 1. Participants in this aim will be scheduled for a visit to complete a heat challenge. At this visit, they will also complete the Participant Info and Temperature Survey. They will also sit in a sauna at 62 - 63 degrees Celsius for 45 minutes.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Previously genotyped as a CF carrier or control
* Comfortable speaking/reading English
Exclusion Criteria:
* Previously genotyped as a CF patient
* Diagnosis of Type 1 or Type 2 diabetes
* History of heart attack, stroke, heart failure, or atherosclerosis
* Currently pregnan…
Inclusion Criteria:
* Previously genotyped as a CF carrier or control
* Comfortable speaking/reading English
Exclusion Criteria:
* Previously genotyped as a CF patient
* Diagnosis of Type 1 or Type 2 diabetes
* History of heart attack, stroke, heart failure, or atherosclerosis
* Currently pregnant
* Currently taking beta blockers or diuretics
* Prisoner status
* Unable to provide own written informed consent
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