Propofol Infusion for Depression in Older Adults
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
Recruiting
Phase 2
Interventional Study
Depression
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 60 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 70 (estimated)
- Sponsor
- Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for older adults aged 60 and over who are experiencing depression. Participants will receive propofol infusions and behavioral therapy to see if these treatments improve their sleep and mood.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 60 years of age or older.
- I speak English.
- I have been diagnosed with depression that hasn't improved with antidepressants.
- I am willing to follow all the study procedures.
- I can provide signed consent to participate.
You may not be able to join if
- I have heart disease or severe heart failure.
- I have had a bad reaction to propofol before.
- I have a resting heart rate below 50 bpm.
- I have taken Electroconvulsive Therapy or Transcranial Magnetic Stimulation in the past 6 weeks.
- My body mass index is over 35.
- I have active suicidal thoughts or a specific plan.
- I have dementia.
- I have schizophrenia or bipolar disorder.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The investigators hypothesize that brief behavioral therapy and targeted propofol infusion in depressed geriatric patients will augment subsequent slow wave sleep and improve clinical and cognitive outcomes. The team will recruit 70 participants for a double-blinded placebo controlled randomized controlled trial. Two propofol infusions, 2-6 days apart, will be administered, targeting either a low …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Provision of signed and dated informed consent form
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Age 60 or greater
* English speaking (as an interpreter will not be readily available should a participant need to conv…
Contacts