Pharmacologic Augmentation of TMS for Depression With D-serine

Recruiting Phase 1 Interventional Study
Depression
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At a Glance
Age
18 – 80
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Mclean Hospital · Other
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About This Trial

The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions of rTMS will produce greater clinical outcomes than iTBS with placebo and 18-Hz with placebo.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Clinical diagnosis of MDD * English-speaking * Adults aged 18-80 * Must be able to swallow capsules Relative contraindications/possible exclusion criteria: * Containing any implanted metal or devices * Current or previous seizure history * Active substance use that may signi…
Contacts

Joshua C Brown, MD, PhD

617-855-2944

jbrown@mclean.harvard.edu

CONTACT

Julia Tom, BS, MSN

617-855-2678

jtom1@mgb.org

CONTACT