No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 55
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
20 (estimated)
Sponsor
Trustees of Dartmouth College · Other
Who this trial is looking for
This trial is looking for people to help understand how different environments and control over pain affect anxiety and memory. Participants will undergo tests that involve managing pain while in various contexts.
Are You a Good Fit for This Trial?
Rules you outSeizure disorderHeart problemsChronic painMajor neurological diagnosis
You may be able to join if
I can read and understand English
I can tolerate high levels of thermal pain stimuli
You may not be able to join if
I have a history of depression or bipolar disorder
I have had a seizure in the past 10 years
I have chronic pain or recent acute pain in the last 3 months
I have a migraine disorder with 15 or more headache days in a month
I have substance abuse issues in the last 6 months
I have heart disease or high blood pressure
I have respiratory problems or severe asthma
I have a neurological condition like a stroke or major brain injury
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior. The study examines how control over pain and threat-related environments influences pain perception, state anxiety, associated autonomic responses, and behavior. The main questions it aims to answer are:
Does having control over pain within specific co…
This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior. The study examines how control over pain and threat-related environments influences pain perception, state anxiety, associated autonomic responses, and behavior. The main questions it aims to answer are:
Does having control over pain within specific contexts alter how much pain people feel-even when the stimulus intensity remains constant? How do different types of environments (safe, controllable, or uncontrollable) shape pain-related brain activity, subjective anxiety, and physiological arousal? How do people perform cognitively demanding or distracting tasks (and retain their memory) when under threat versus when in control? Lastly, how do these learned associations with spatial contexts persist or adapt when environmental contingencies are explicitly changed?
Taken together, exploration of these factors may lay the groundwork for understanding how placebo-related mechanisms-including perceived control, contextual learning, emotional engagement, and distraction-interact to shape pain and anxiety in complex environments.
Trial Locations
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Eligibility Criteria
* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis
* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis
* No self-reported current chronic pain, or acute pain wi…
* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis
* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis
* No self-reported current chronic pain, or acute pain within three months of the study period
* No current migraine disorder (i.e., 15 headache days or more in 1 month)
* No use of central nervous system-effective medication or other medication for neurological/psychiatric treatment
* No self-reported substance abuse within the last six months
* No contraindication to MRI (e.g., pregnancy, claustrophobia, pacemakers, ear/cochlear implants, shrapnel injuries, clips, or other ferromagnetic/electrical objects/devices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)
* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)
* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English
* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)
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