No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
40 (estimated)
Sponsor
University of Cincinnati · Other
Who this trial is looking for
This trial is looking for adults who have recently had a stroke caused by a blood clot. Participants will undergo specialized imaging after receiving treatment to help understand which parts of the brain are still at risk of damage.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years old or older.
My last known normal state was within the last 24 hours.
I have had a stroke caused by a significant blockage in my brain's blood vessels.
I have had a successful procedure to remove the blood clot.
You may not be able to join if
I have severe kidney problems.
I cannot have contrast dye used in imaging.
I cannot undergo magnetic resonance imaging (MRI).
I have had a major stroke previously in the same brain area.
I have blockages in both the main artery and the brain vessel.
I have had more than four attempts to remove a blood clot.
I am currently enrolled in another stroke treatment study.
I am pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain. These blood clots interrupt the normal flow of blood and oxygen to the nerve cells in the brain. When this occurs, the nerve cells can die, causing permanent damage to that area of the brain. That damage can result in loss of normal function to…
Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain. These blood clots interrupt the normal flow of blood and oxygen to the nerve cells in the brain. When this occurs, the nerve cells can die, causing permanent damage to that area of the brain. That damage can result in loss of normal function to a patient's vision, strength, sensation, balance, or speech. These changes can remain permanent if blood flow is not restored to the brain. Thankfully, there are treatments available to help get rid of these blood clots. One of these treatments is a procedure to physically remove the blood clot causing stroke. This practice is now routinely done at all major stroke centers.
Special imaging for stroke is now available at these major stroke centers. This imaging looks at blood flow in and around the area of brain that is dying. By performing these scans after the procedure, we can see that not all of brain is being saved by the procedure. That is a problem, because we know that saving brain cells can make a big difference in how patients recover from stroke. The purpose of this study is to determine which brain tissue will not get saved by blood clot removal. We will do this by using specialized imaging after the procedure. The study will discover if there is more brain tissue that can be saved after the procedure. Once we can determine this, our next steps will be looking at ways to save this tissue in the studies that follow. For example, we will look to see if medications can be given after the procedure to help save those brain areas. This study lays the groundwork for future studies to help save all the brain tissue we possibly can from dying during the stroke. This is our best chance of getting all patients affected by stroke the opportunity to live their best lives after stroke.
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Eligibility Criteria
Inclusion Criteria:
* Adults greater than or equal to 18 years of age
* Last known normal (LKN) within 24 hours
* Ischemic stroke due to anterior circulation LVO (intracranial internal carotid artery \[ICA\], proximal middle cerebral artery \[M1\], M1/M2 bifurcation, or proximal dominant M2 occlusi…
Inclusion Criteria:
* Adults greater than or equal to 18 years of age
* Last known normal (LKN) within 24 hours
* Ischemic stroke due to anterior circulation LVO (intracranial internal carotid artery \[ICA\], proximal middle cerebral artery \[M1\], M1/M2 bifurcation, or proximal dominant M2 occlusion)
* mTICI2c or mTICI3 on digital subtracted angiography (DSA) following mechanical thrombectomy
Exclusion Criteria:
* Significant renal insufficiency (glomerular filtration rate \<30mg/ml/min2 while not on dialysis)
* Contraindication to iodinated contrast
* Contraindication to magnetic resonance imaging (e.g., pacemaker incompatibility)
* Prior significant stroke in same vascular territory ipsilateral stroke
* Tandem vessel occlusion (i.e., extracranial ICA and ipsilateral intracranial M1/M2 occlusion)
* Greater than 4 clot retrieval attempts
* Enrollment in another acute stroke interventional study (with the exception of thrombectomy device registries)
* Pregnancy
* Prisoners
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