Insulin Secretion Study for Diabetes
Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.
Recruiting
Phase 1
Interventional Study
Diabetes (DM)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 60
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 30 (estimated)
- Sponsor
- David D'Alessio, M.D. · Other
Who this trial is looking for
This trial is looking for adults aged 18-60 with diabetes or insulin resistance. Participants will help researchers understand insulin and glucose management by possibly undergoing tests and examinations.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 60 years old
- I have a Body Mass Index (BMI) within the specified range
- I have a fasting plasma glucose or HbA1c value within the specified range
You may not be able to join if
- I have an active medical disease
- I have a history of diabetes or pancreatitis
- I have a history of cardiac, gastrointestinal, renal or liver disease
- I have a family history of diabetes
- I have renal insufficiency
- I have anemia
- I am pregnant
- I have poor vein access
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Glucagon secretion from α-cells has long been viewed as primarily a counterregulatory mechanism - e.g. an agent with a role to prevent blood sugar from decreasing to levels that compromise function. Our group, along with other researchers, have begun to identify a much more complex role for α-cells, raising questions about when and how glucagon may influence blood glucose levels. This proposal loo…
Trial Locations
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Eligibility Criteria
Aim 2A and 2A sub-study: Inclusion Criteria:
* Age 18-45
* Body Mass Index (BMI) \< 27.0
* Fasting plasma glucose of ≤ 95 mg/dL or HbA1c value ≤ 5.8% as measured at screening visit
Exclusion Criteria:
* Active medical disease: e.g. active infectious, inflammatory, neurodegenerative or mental heal…
Contacts