Dexamethasone vs Prednisone for Asthma Attacks

Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department

Recruiting Phase 4 Interventional Study
Asthma
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
182 (estimated)
Sponsor
Montefiore Medical Center · Other
Who this trial is looking for

This trial is looking for adults with asthma who are having an attack and need treatment in the emergency department. Participants will receive either an injection of dexamethasone or a 5-day course of prednisone.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am at least 18 years old.
  • I have been diagnosed with asthma.
  • I am having an asthma attack.
  • I will start medications for my asthma during my visit.
  • I can speak English or Spanish.

You may not be able to join if

  • I am currently taking systemic corticosteroids.
  • I have had severe reactions to corticosteroids.
  • I have heart failure.
  • I have uncontrolled diabetes.
  • I am pregnant or breastfeeding.
  • I cannot provide informed consent.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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Answer a few quick questions to see if you may meet the eligibility requirements.

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About This Trial

This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Adults ≥18 years old presenting to the ED with an asthma exacerbation * Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician * Discharged from the ED with a primary diagnosis of asthma exacerbation * I…
Contacts

Mustfa Manzur, MD MPH MS

718-920-6626

mmanzur@montefiore.org

CONTACT