No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
12 (estimated)
Sponsor
Celldex Therapeutics · Industry
Who this trial is looking for
This trial is looking for adults with mild to moderate asthma who want to test a new treatment. Participants will take the treatment and follow up on their asthma symptoms and health for safety and effectiveness.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I have been diagnosed with mild to moderate asthma for at least 12 months.
I have good lung function as measured by FEV1.
I have shown improvement in lung function after taking a bronchodilator.
I agree to use contraception during the study and for 150 days after treatment.
I am willing to follow all study procedures.
You may not be able to join if
I am pregnant or nursing.
I have another lung disease besides asthma.
I have a history of severe asthma attacks or needed hospitalization for asthma treatment in the past year.
I have current nasal polyps.
I have a severe form of asthma that is not controlled.
I have smoked or vaped in the past 6 months.
I have an active infection like tuberculosis, hepatitis B or C, or HIV.
I have received certain biologic therapies in the past 3 months.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This is a study to determine the safety, pharmacodynamics (PD), and pharmacokinetics (PK) of CDX-622 in adults with mild to moderate asthma.
Trial Locations
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Eligibility Criteria
Key Inclusion Criteria:
1. Males and females, ≥ 18 years of age
2. Diagnosis of mild to moderate asthma for at least 12 months
3. Pre-bronchodilator forced expiratory volume in 1 second (FEV1) ≥ 70% of predicted normal
4. Airway reversibility ≥ 12% and 200 mL improvement in FEV1
5. Both males and f…
Key Inclusion Criteria:
1. Males and females, ≥ 18 years of age
2. Diagnosis of mild to moderate asthma for at least 12 months
3. Pre-bronchodilator forced expiratory volume in 1 second (FEV1) ≥ 70% of predicted normal
4. Airway reversibility ≥ 12% and 200 mL improvement in FEV1
5. Both males and females of child-bearing potential must agree to use contraception during the study and for 150 days after treatment
6. Willing and able to comply with all study requirements and procedures
Key Exclusion Criteria:
1. Females who are pregnant or nursing
2. Pulmonary disease other than asthma
3. Systemic diseases with elevated eosinophils other than asthma
4. Hospitalization for treatment of asthma in the past 12 months or required oral corticosteroids due to asthma within the past 6 months
5. History of needing ventilator support due to asthma
6. Current nasal polyps
7. Severe or uncontrolled asthma
8. History of smoking or vaping within the past 6 months
9. Tuberculosis, hepatitis B or C virus, or HIV
10. Immunomodulating biologic therapies within the past 3 months for non-extended half-life biologics.
11. Prior receipt of TSLP or KIT inhibitors such as tezepelumab or briquilimab
Additional protocol defined inclusion and exclusion criteria could apply.
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