No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 80
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
20 (estimated)
Sponsor
Medical University of South Carolina · Other
Who this trial is looking for
This trial is looking for people with major depressive disorder who are already receiving a TMS treatment at MUSC. Participants will practice mindfulness daily while undergoing their TMS course to see if this helps improve their mood.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with major depressive disorder.
I am enrolled in a TMS course at MUSC.
I speak English.
I have a smartphone or will use a study-provided device.
You may not be able to join if
I have a history of seizures or have implants.
I am pregnant.
I am receiving other neuromodulation treatments.
I have a psychotic disorder or bipolar disorder.
I have an active substance use disorder.
I am at high risk for suicide.
I cannot or do not want to engage in mindfulness practice.
I cannot complete questionnaires.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the res…
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the research intervention is daily guided mindfulness practice during the aiTBS course. Outcomes include feasibility/acceptability, changes in state mindfulness and hedonic tone (Day 0 to Day 5), perceived ease of meditation, trait mindfulness at 4 and 12 weeks, and durability of antidepressant response (PHQ-9) at 4 and 12 weeks.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Clinical diagnosis of MDD and eligible for aiTBS at MUSC
* Already enrolled in aiTBS course at MUSC
* English proficiency
* Smartphone or willingness to use study-provided device
Exclusion Criteria:
* TMS contraindications (e.g., seizure history, implants, pregnancy)
* Concu…
Inclusion Criteria:
* Clinical diagnosis of MDD and eligible for aiTBS at MUSC
* Already enrolled in aiTBS course at MUSC
* English proficiency
* Smartphone or willingness to use study-provided device
Exclusion Criteria:
* TMS contraindications (e.g., seizure history, implants, pregnancy)
* Concurrent neuromodulation (ECT, VNS)
* Psychotic disorder, bipolar disorder, active substance use disorder, high suicide risk
* Unable/unwilling to engage in mindfulness or complete questionnaires
Contacts
No contact information available.
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