No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
15 – 25
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
25 (estimated)
Sponsor
University of California, Davis · Other
Who this trial is looking for
This trial is looking for young people aged 15-25 who have mild to severe depression. Participants will receive a non-active version of a brain treatment over five days and will have assessments before and after the treatment.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 15 and 25 years old
I speak English
I have been diagnosed with depression
I can give consent (or assent if I'm under 18)
You may not be able to join if
I have had Transcranial Magnetic Stimulation in the past
I cannot consent due to a medical condition or mental health issue
I am in an acute suicidal crisis
I have an active medical illness that interferes with participation
I have metal in my body that affects MRI safety
I have major neurological problems such as a seizure disorder
I have participated in another clinical study with treatment in the last 30 days
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimulation (TMS) treatment. No active brain stimulation is given.
The main questions this study aims to an…
The goal of this clinical study is to understand how a person's expectations about treatment can influence their mood, motivation, and reactions to everyday rewards. The study includes young people ages 15-25 who will complete a sham (placebo) version of an accelerated transcranial magnetic stimulation (TMS) treatment. No active brain stimulation is given.
The main questions this study aims to answer are:
1. Do expectancy and treatment beliefs change during and after an accelerated sham TMS schedule?
2. Do these expectations influence mood, reward processing, or craving?
3. Does a more intensive schedule of sham sessions lead to different expectancy effects than a slower, once-daily schedule?
Participants will:
* Complete baseline clinical assessments and an MRI session
* Undergo five days of accelerated sham TMS (no active brain stimulation is delivered)
* Complete post-treatment MRI and follow-up assessments at 1 week and 4 weeks
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* English speaking
* Able to provide informed consent (and assent if \< 18 years)
* 15-25 years old
* Slight-to-severe symptoms of depression
Exclusion Criteria:
* Past exposure to Transcranial Magnetic Stimulation
* Unable to consent (due to medical condition, psychosis, subs…
Inclusion Criteria:
* English speaking
* Able to provide informed consent (and assent if \< 18 years)
* 15-25 years old
* Slight-to-severe symptoms of depression
Exclusion Criteria:
* Past exposure to Transcranial Magnetic Stimulation
* Unable to consent (due to medical condition, psychosis, substance use, etc)
* Acute suicidal crisis or with active medical illness that would interfere with participation
* Contraindications to receiving MRI as determined by screening questionnaires (Contraindications for MRI include metal in the body related to an injury or surgery, for example, surgical clips, metal fragments in the eyes, or piercings that cannot be removed. Subjects with braces or permanent retainers will not be scanned, because the effects on image signal are not well understood and may affect comparability between subjects and scan sites. Participants will be excluded for major neurological problems, such as seizure disorder, traumatic brain injury with loss of consciousness, or sensory problems that may impair task performance, such as blindness.)
* Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies
Contacts
No contact information available.
What are you hoping to find?
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.