No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
25 – 45
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
70 (estimated)
Sponsor
University of Colorado, Denver · Other
Who this trial is looking for
This trial is looking for adults aged 25-45 who are overweight and willing to try daily snacks of walnuts or pretzels. Participants will help researchers understand how different snacks affect the brain while dieting.
Are You a Good Fit for This Trial?
Must not be takingInjectable diabetes medicationsWeight-loss medicationsSteroids
Rules you outCurrent eating disorderSignificant endocrine/metabolic diseaseHeavy neurological illness or injury
You may be able to join if
I am 25-45 years old
My BMI is at least 27
I am comfortable completing a weight-loss program
I am willing to eat a daily snack of walnuts or pretzels
You may not be able to join if
I have a nut or wheat allergy
I have had bariatric surgery
I currently have an eating disorder
I am using illegal substances
I am currently pregnant or breastfeeding
I have uncontrolled high blood pressure
I have a serious medical condition affecting my kidneys, liver, or blood
I have had a significant mental health change recently
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* 25-45 years old
* BMI at least 27 kg/m2
* Comfortable completing a weight-loss intervention\\
* Willing to consume a daily snack of either walnuts or pretzels
Exclusion Criteria:
* Nut or wheat allergy
* History of bariatric surgery
* Current eating disorder
* Current illici…
Inclusion Criteria:
* 25-45 years old
* BMI at least 27 kg/m2
* Comfortable completing a weight-loss intervention\\
* Willing to consume a daily snack of either walnuts or pretzels
Exclusion Criteria:
* Nut or wheat allergy
* History of bariatric surgery
* Current eating disorder
* Current illicit substance use
* Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum
* Uncontrolled hypertension (\>160/100 mmHg)
* Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results
* Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment
* Taking weight-loss medications, or steroids within \~3 months prior to study participation (e.g., GLP-1 receptor agonists)
* Significant mental health changes within \~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns)
* Neurological illnesses or injury that would be anticipated to affect MRI data
* Weight change greater than 10% within 3 months prior to study participation
* Currently participating in another weight-loss study
* Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan)
* MRI-specific exclusion criteria (e.g., metal in the body, weight \>500 lbs
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