Dexamethasone vs Methylprednisolone for Critical Asthma
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Recruiting
Phase 2
Interventional Study
Asthma (Diagnosis)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 3 – 17
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 159 (estimated)
- Sponsor
- Johns Hopkins All Children's Hospital · Other
Who this trial is looking for
This trial is looking for children aged 3 to 17 who are hospitalized for severe asthma. Participants will receive one of three different treatments to help manage their condition.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 3 and 17 years old
- I have been admitted to the intensive care unit
- I am being treated for critical asthma
You may not be able to join if
- I have a history of unrepaired critical congenital heart disease
- I have a history of cystic fibrosis
- I am currently dependent on a tracheostomy
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue among the expert medical community regarding the superiority of specific SCs including dose, frequency of administration, route, and delivery. Regimens are often chosen base…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 3-17 years
* Intensive care unit admission
* Treatment for critical asthma
Exclusion Criteria:
* History of unrepaired critical congenital heart disease
* History of cystic fibrosis
* Active tracheostomy dependence
Contacts