No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 59
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
40 (estimated)
Sponsor
Arkansas Colleges of Health Education · Other
Who this trial is looking for
This trial is looking for adults who want to lose weight and improve their heart health through exercise. Participants will take part in a 16-week exercise program performed either before or after eating to see which method is more effective.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 59 years old
I have a BMI between 25 and 45
I am healthy enough to exercise
You may not be able to join if
I take medications that affect energy use
I currently exercise more than once a week
I am dieting for weight loss
I take weight loss drugs
I have had weight loss surgery
I have diabetes
I have heart disease
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. When exercise also produces weight loss, these benefits are much improved. Although using exercise to…
Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. When exercise also produces weight loss, these benefits are much improved. Although using exercise to treat or prevent heart disease / obesity is recommended, not all people respond well. Some see significant weight loss and health improvements while others see little changes. For these reasons, new strategies surrounding the use and design of an exercise program are needed. One such strategy could be performing aerobic exercise before breakfast (fasted exercise). When exercising fasted, food/energy stores are low, and one relies on stored body fat for energy. This may help heart health and weight loss. This has never been tested in a program long enough to see such changes. This study will, for the first time, assess the effects of a 16-week aerobic exercise program performed fasted compared to after eating. Outcomes will include blood fats, blood pressure, fat-burning abilities and weight loss.
Starting an exercise program can also make people to eat more. This limits the success of exercise. The study will also evaluate ways fasted exercise could change eating, as it possible that fasted exercise could also cause people to eat more, which would limit weight loss and health improvements.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Aged 18-59
* BMI 25-45
* Healthy enough to exercise
Exclusion Criteria:
* Taking medications or supplements that are known to influence energy expenditure,
* Currently exercising more than once per week
* Currently dieting for weight loss
* Currently taking weight loss drugs…
Inclusion Criteria:
* Aged 18-59
* BMI 25-45
* Healthy enough to exercise
Exclusion Criteria:
* Taking medications or supplements that are known to influence energy expenditure,
* Currently exercising more than once per week
* Currently dieting for weight loss
* Currently taking weight loss drugs
* Have had a previous weight loss surgery
* Currently diagnosed with Diabetes
* Currently diagnosed with heart disease (Heart failure, uncontrolled hypertension, uncontrolled hypercholesterolemia, Coronary heart disease)
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