No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
60 and older
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
10 (estimated)
Sponsor
Oklahoma Medical Research Foundation · Other
Who this trial is looking for
This trial is looking for older adults (60+) with Multiple Sclerosis. Participants will engage in an exercise program over approximately 4 months, attending about 3 sessions each week.
Are You a Good Fit for This Trial?
Must not be takingMetforminHigh dose statins
Rules you outChronic kidney diseaseAlzheimer's diseaseCurrent cancer diagnosisCerebrovascular disease
You may be able to join if
I am 60 years old or older
I have been diagnosed with Multiple Sclerosis
I do not have unmanaged chronic diseases other than MS
I have not been part of a structured exercise program in the last 6 months
I am able to provide informed consent
I have an EDSS score between 2 and 5.5
You may not be able to join if
I have a neuromuscular or musculoskeletal disorder affecting exercise
I have a cardiopulmonary disorder or breathing issues
I have metabolic diseases like liver disease or type 2 diabetes
I take metformin or any insulin-sensitizing drugs
I have another disease that could affect my exercise response
I have a history of chemotherapy in the last 5 years
I have a lidocaine allergy
I use tobacco or consume excessive alcohol
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (\>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if …
The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (\>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if or how individuals diagnosed with MS adapt differently than age-matched people without MS to exercise training. Participation in this study will average 1.5 hours per visit, 3 visits per week, for approximately 4 months.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 1\. Male or female aged 60 or above 2. Free of unmanaged chronic diseases other than multiple sclerosis 3. No structured exercise program (2 or more bouts/wk) within previous 6 months 4. Cognitively capable of providing informed consent 5. Must meet EDSS score between 2 to 5.5…
Inclusion Criteria:
* 1\. Male or female aged 60 or above 2. Free of unmanaged chronic diseases other than multiple sclerosis 3. No structured exercise program (2 or more bouts/wk) within previous 6 months 4. Cognitively capable of providing informed consent 5. Must meet EDSS score between 2 to 5.5 during screening
Exclusion Criteria:
* 1\. Neuromuscular or musculoskeletal disorder, other than multiple sclerosis, that would limit the ability to perform the exercise and/or testing bouts.
2\. Cardiopulmonary disorders or reduced breathing capacity
3\. Metabolic diseases including markers of liver disease (ALT \> 52 U/dl) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl)
4\. Taking any dose of metformin
5\. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, Alzheimer's, current cancer diagnosis or within 2 yr remission, cerebrovascular)
6\. History of Chemotherapy within 5 years
7\. Unchangeable anticoagulant (Coumadin, Pradaxa, etc.) use. To be determined by clinical staff.
8\. Insulin sensitizing/blood glucose lowering (e.g., metformin) or metabolic (GLP1 agonists) drugs.
9\. High dose statin (40 mg and above)
10\. Have a non-correctable visual impairment
11\. Score less than 29 on the Symbol Digit Test
12\. Received Botox for spasticity within the prior 3 months of study participation.
13\. Cannot have any adjustments to Baclofen during study participation.
13\. Unable to commit to \~4 months required to complete the study.
14\. Lidocaine allergy
15\. Tobacco use
16\. Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/day or drinks/wk for males)
17\. BMI greater than 35.0 kg/m2
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