New Imaging Test for Heart and Lung Diseases
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
Recruiting
Phase 3
Interventional Study
Allogeneic Stem Cell Transplantation
Lung Allograft Transplantation
Interstitial Lung Disease
Acute Lung Injury
Pulmonary Arterial Hypertension
Cardiovascular Diseases
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 100
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 210 (estimated)
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI) · NIH
Who this trial is looking for
This trial is looking for adults with heart or lung diseases that might cause scarring. Participants will undergo a series of imaging tests over two years to help researchers learn more about these conditions.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old.
- I have been diagnosed with a heart or lung disease.
- I have had prior imaging of my lungs or heart.
- I can lie still for about 45 minutes during imaging.
- I understand and can sign a consent form.
You may not be able to join if
- I have had allergic reactions to similar substances used in this study.
- I have a serious illness that affects my ability to follow the study.
- I am currently pregnant or breastfeeding.
- I have severe claustrophobia that cannot be managed.
- I weigh more than 350 lbs or cannot fit in the imaging machine.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Background:
Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to detect the fibrosis in its earliest stages, while there might still be time to prevent serious damage. A new tracer (a radioactive substance injected during imaging scan…
Trial Locations
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Eligibility Criteria
* INCLUSION CRITERIA
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Parti…
Contacts