No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
2,000 (estimated)
Sponsor
University of California, San Francisco · Other
Who this trial is looking for
This trial is looking for patients who are unconscious from serious brain issues. Participants will be observed during their hospital stay and followed up after discharge to assess recovery over time.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I have been in a coma for at least 24 hours.
I am unconscious due to a neurological issue.
I was admitted to the intensive care unit.
You may not be able to join if
I had a limited motor score before being admitted to the hospital.
I was transferred from another hospital, and my motor score isn't known.
My coma is caused by sepsis or metabolic problems.
I have a focal brain lesion that affects my ability to follow commands.
I am a prisoner.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest, traumatic brain injury, seizures, brain infection, or other neurologic emergencies may be enrolled during their hospitalization.
The purpose of this observational research st…
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest, traumatic brain injury, seizures, brain infection, or other neurologic emergencies may be enrolled during their hospitalization.
The purpose of this observational research study is to learn which medical, neurologic, psychological, and social factors are associated with recovery over time. Researchers will collect information from the medical record during hospitalization, including details about the patient's illness, treatments received, brain imaging, and neurologic examinations.
For patients who survive hospitalization, the study team will contact participants or their caregivers after discharge to assess recovery at scheduled time points using questionnaires and structured interviews about physical function, quality of life, emotional well-being, and daily activities.
This study does not assign participants to any experimental treatment. Participation will not change the medical care patients receive. Information learned from this study may help improve future care for patients with coma and disorders of consciousness.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Age greater than or equal to 18 years on the day of hospital admission
* Coma duration of at least 24 hours from presentation to the receiving hospital, or died prior to the 24 hour timepoint without return of consciousness. Coma defined as: GCS score of less than or equal to …
Inclusion Criteria:
* Age greater than or equal to 18 years on the day of hospital admission
* Coma duration of at least 24 hours from presentation to the receiving hospital, or died prior to the 24 hour timepoint without return of consciousness. Coma defined as: GCS score of less than or equal to 10 AND GCS score of less than 6 on the motor component of the GCS(not following commands) AND GCS score less than 3 on the verbal component AND alteration of consciousness not explained by sedation only
* Coma due to a neurological process (Including but not limited to: trauma, stroke, hypoxic- ischemic brain injury (HIBI), CNS infection, seizure, other processes at the discretion of the investigator)
* Admission to the intensive care unit, or deceased prior to admission.
Exclusion Criteria:
* Pre-existing score of 5 or less on the motor component of the Glasgow Coma Scale prior to hospital admission.
* Transfer from another acute care hospital in which the motor component of the Glasgow Coma Scale on the day after initial hospital arrival is not known or cannot be reconstructed from medical records or history.
* Coma due to sepsis, systemic metabolic processes (ex: organ failure or sedation).
* GCS score of greater than 2 for eye opening with lack of command following due to a focal brain lesion causing receptive aphasia.
* Prisoner
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