No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
264 (estimated)
Sponsor
Kymera Therapeutics, Inc. · Industry
Who this trial is looking for
This trial is looking for individuals with asthma who have previously taken part in another KT-621 study. Participants will take the KT-621 treatment and attend regular visits for monitoring and assessments.
Are You a Good Fit for This Trial?
You may be able to join if
I have completed all visits of the previous KT-621 study.
I am willing to attend scheduled visits and follow the treatment plan.
I agree to use contraception as required by the study.
You may not be able to join if
I have had a significant change in my health during the previous study.
I developed any adverse effect that may pose a risk if I continue treatment.
I stopped taking the previous study treatment for any reason.
I am part of the research team or related to someone on the team.
I am unable to follow the study's procedures.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This Phase 2b open-label, long-term extension study is designed to evaluate the long-term safety and efficacy of KT-621 in participants with asthma who were previously enrolled in the parent study (KT621-AS-202) of KT-621 for asthma. The main goals of this study are to investigate the long-term safety and tolerability of KT-621, the long-term efficacy of KT-621 at treating asthma, and how KT-621 b…
This Phase 2b open-label, long-term extension study is designed to evaluate the long-term safety and efficacy of KT-621 in participants with asthma who were previously enrolled in the parent study (KT621-AS-202) of KT-621 for asthma. The main goals of this study are to investigate the long-term safety and tolerability of KT-621, the long-term efficacy of KT-621 at treating asthma, and how KT-621 behaves in the body long-term.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Must have completed all visits of the parent study, per its protocol, up to the end of treatment (EoT) visit.
* Must be willing and able to comply with scheduled visits, treatment plan, laboratory tests, other study-related procedures, and questionnaires, including completing …
Inclusion Criteria:
* Must have completed all visits of the parent study, per its protocol, up to the end of treatment (EoT) visit.
* Must be willing and able to comply with scheduled visits, treatment plan, laboratory tests, other study-related procedures, and questionnaires, including completing the electronic diary (e-diary), for the duration of the study as required by the study protocol.
* Must agree to contraceptive requirements in compliance with the clinical study and local requirements.
Exclusion Criteria:
* Must not have experienced any clinically significant change in health status during the parent study, which, in the opinion of the Investigator, would interfere with participant safety, study evaluations, or compliance with study procedures; or otherwise make the participant unsuitable for participation in this study.
* Must not have developed an AE during the parent study, that in the opinion of the Investigator or of the Sponsor's Medical Monitor, could indicate that continued treatment may present an unreasonable risk for the participant.
* Must not have met permanent discontinuation criteria and/or permanently discontinued study treatment for any reason during the parent study.
* Must not be a member of the Sponsor or site's investigational team or their immediate family.
* Must not be unsuitable to enter the study for any other reason, as judged by the Investigator, including potential risk of noncompliance to study procedures.
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