rTMS for Bipolar Disorder Depression

Neuromodulation of Mood Switch Circuitry in Bipolar Disorder

Recruiting Phase 4 Interventional Study
Bipolar Disorder (BD) Bipolar 1 Depression rTMS fMRI
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 70
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
62 (estimated)
Sponsor
Weill Medical College of Cornell University · Other
Who this trial is looking for

This trial is looking for adults with bipolar disorder who experience depression. Participants will receive two rounds of brain stimulation treatment to understand how it can help improve mood.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between 18 and 70 years old.
  • I have been diagnosed with bipolar disorder.
  • I have moderate or more severe depressive symptoms.
  • I am not currently taking bipolar disorder medications or have been on a stable dose for at least 1 month.
  • I have access to psychiatric care during the study.
  • I can communicate in English well enough for the study.
  • I am willing to follow all study procedures.
  • I agree to use effective contraception if I can get pregnant.

You may not be able to join if

  • I am at risk of suicide.
  • I have a different primary psychiatric diagnosis.
  • I have a history of seizures or conditions that lower seizure threshold.
  • I have a significant heart condition.
  • I have had any significant neurological disorder.
  • I am pregnant, breastfeeding, or planning to become pregnant.
  • I have an MRI contraindication.
  • I have abnormal bloodwork for electrolytes, thyroid, or liver function.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
This study is exploring a new approach to treating depression in people with bipolar disorder (BD). Investigators are testing whether a non-invasive form of brain stimulation can help us understand depressed-to-euthymic mood shifts and their related brain circuits in BD. Investigators in this study will use a technique called repetitive transcranial magnetic stimulation, or rTMS. It uses non-inva…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Adults of all genders aged 18-70 at the time of screening. 3. Diagnosis of Bipolar Disorder (by DSM-V criteria) 4. Depressive symptoms of at least moderate severity (GRID HDRS-17 score \>= 14 or as determined by expert c…
Contacts

Research Coordinator, Interventional Psychiatry Program

646-962-2900

tmsinfo@med.cornell.edu

CONTACT