No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 64
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Prevention
Participants needed
200 (estimated)
Sponsor
BioNTech SE · Industry
Who this trial is looking for
This trial is looking for healthy adults aged 18 to 64 years to study the safety and effects of an updated COVID-19 vaccine. Participants will receive one injection and be in the study for about 12 months.
Are You a Good Fit for This Trial?
You may be able to join if
I am healthy and between 18 and 64 years old
I do not have medical conditions that increase my risk for severe COVID-19
You may not be able to join if
I tested positive for COVID-19 within the last 6 months
I have recently received another vaccine
I plan to receive a COVID-19 vaccine during the study
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to learn about the safety and effects of an updated COVID-19 vaccine (called BNT162b2) in adults 18 to 64 years of age.
This study is seeking participants who:
* are medically stable
* have not had a recent COVID-19 infection
* have not had a recent vaccination
* do not have medical conditions that increase their risk of complications from COVID-19
All participants …
The purpose of this study is to learn about the safety and effects of an updated COVID-19 vaccine (called BNT162b2) in adults 18 to 64 years of age.
This study is seeking participants who:
* are medically stable
* have not had a recent COVID-19 infection
* have not had a recent vaccination
* do not have medical conditions that increase their risk of complications from COVID-19
All participants in this study will randomly receive 1 injection into their arm of either:
* BNT162b2 vaccine which targets COVID-19 and is selected for the 2026-2027 COVID-19 season, or
* Tdap vaccine which targets tetanus, diphtheria, and pertussis (whooping cough).
The study team and participants will not know which injection they receive. We will evaluate safety and SARS-CoV-2 spike protein levels in people receiving each of these vaccines.
Participants will be in the study for about 12 months.
Trial Locations
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City
State
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Status
Eligibility Criteria
Key Inclusion Criteria
\- Healthy participants 18 through 64 years of age who do not have medical conditions that put them at a higher risk for severe COVID-19.
Key Exclusion Criteria
* Participants who tested positive for COVID-19 within 6 months (180 days) prior to Visit 1
* Participants who ha…
Key Inclusion Criteria
\- Healthy participants 18 through 64 years of age who do not have medical conditions that put them at a higher risk for severe COVID-19.
Key Exclusion Criteria
* Participants who tested positive for COVID-19 within 6 months (180 days) prior to Visit 1
* Participants who have recently received a vaccine, or plan to receive a nonstudy COVID-19 or comparator vaccine during participation.
The complete list of inclusion and exclusion criteria are listed in the protocol.
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