Parkinson's Disease in Type 1 Gaucher Disease
Recruiting
Observational Study
Parkinson Disease (PD)
Type 1 Gaucher Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 40 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 100 (estimated)
- Sponsor
- Icahn School of Medicine at Mount Sinai · Other
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About This Trial
Parkinson's disease (PD) is an age-related movement disorder with a complex pathophysiology. Among the risk factors for PD, variants in beta-glucocerebrosidase (encoded by the gene GBA1) represent one of the most significant heritable risk factors for lifetime PD risk. Biallelic variants in GBA1 cause Gaucher disease (GD), a multisystem disorder, and individuals with late/adult-onset GD1 have a \~…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Subjects with a documentation of GBA1 phenotype
* Subjects older than 40 years old
* Either GD1 participants with or without PD
* GBA1 heterozygotes with or without PD
* Non-carrier controls without neurological disorder and no first-degree family relative with PD
Exclusion C…
Contacts