Berobenatide for Knee Osteoarthritis in Overweight Adults
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
Recruiting
Phase 3
Interventional Study
Obesity
Overweight
Osteoarthritis of the Knee
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 656 (estimated)
- Sponsor
- Pfizer · Industry
Who this trial is looking for
This trial is looking for adults with knee pain who are overweight or have obesity. Participants will receive either the study medicine berobenatide or a placebo for a year to see how it affects their knee pain and weight.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old.
- I have a body mass index of at least 27.
- I have been diagnosed with knee osteoarthritis.
- I experience pain in my knee.
- I have a knee x-ray showing signs of osteoarthritis.
- I am willing to stop taking certain pain medications before the study.
- I have tried to lose weight before but was not successful.
You may not be able to join if
- I have gained or lost more than 5% of my weight in the last 90 days.
- I have a history of diabetes.
- I have issues with how my stomach empties.
- I have a personal or family history of medullary thyroid carcinoma.
- I have a serious or unstable mental health condition.
- I have a condition that may affect my knee pain assessment.
- I am scheduled for knee surgery during the study.
- I have participated in a berobenatide study before.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity. The study will last 52 weeks and compare the effects of berobenatide compared to placebo on knee pain, physical function, and body weight. Study activities will include blood tests, knee pain assessment, physical fu…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults 18 years of age or older, or the minimum age of consent according to local regulations.
* Body mass index of at least 27 kg/m² at Screening.
* Currently meets American College of Rheumatology (ACR) Criteria for knee OA.
* Pain due to knee OA.
* Knee radiograph consisten…
Contacts