Adalimumab for Major Depressive Disorder
Precision Depression Adalimumab Trial
Recruiting
Phase 2
Interventional Study
Major Depressive Disorder (MDD)
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 60 (estimated)
- Sponsor
- Daniel Moriarity · Other
Who this trial is looking for
This trial is looking for adults with Major Depressive Disorder who are taking Lexapro. Participants will receive either the study medication adalimumab or a placebo every two weeks and fill out daily surveys for 57 days.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old.
- I have been diagnosed with Major Depressive Disorder.
- I am taking Lexapro for at least the last 4 weeks.
- I can take oral medications and injections.
- I will use effective contraception if female and able to become pregnant.
- I have signed the informed consent form.
- I have access to a phone or computer with a camera.
You may not be able to join if
- I am pregnant or breastfeeding.
- I have a current infection.
- I have a known cancer.
- I have a current autoimmune condition.
- I have a history of severe immune conditions.
- I have a history of a demyelinating disease.
- I have a history of seizure disorder.
- I have a substance use disorder.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
The goal of this clinical trial is to learn if the anti-inflammatory medication adalimumab improves depressive symptoms in adults with Major Depressive Disorder (MDD) who are already taking the anti-depressant medication Lexapro (escitalopram).
The main questions it aims to answer are:
1. Does adalimumab improve the symptoms of some patients with MDD who are already taking an anti-depressant?
2.…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Provision of signed and dated informed consent form
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Male or female, aged 18+ years
* Meet DSM-5 criteria for Major Depressive Disorder
* baseline serum TNF-alpha (average …
Contacts